AVISO Healthcare - Frequently Asked Question's About DNA Tests
Q. Why should anyone choose to get tested at AVISO Healthcare?
AVISO Healthcare provides DNA Tests only for those predispositions which have reliable data via strong research with biomarkers that not only cover Wellness Skin Immunity Cardiomed for Consumers but also prevail in Clinical Genomics and Pharmacogenomics including Bio-Informatics, Clinical Diagnosis including R&D for Enterprise. AVISO Healthcare engages with a state-of-the-art genomics laboratory comprising team of highly skilled molecular biologists, computational biologists, bio-informaticians, data scientists.
AVISO Healthcare provides personalized care, genuine concern and a sincere commitment to the overall well-being of its customers/patient(s). On request we provide Medical IOT devices and supports Rehabilitation services from our IT SAS platform enabling real-time information to Caregivers | Patients | Doctors | Guardians.
At AVISO Healthcare, we believe in preventive and non-invasive treatment as we fill the service gap in the healthcare delivery system and offer a continuum of care to patients.
Q. Why can’t any other labs not do this test?
Doing a DNA test requires the following - A state of the art genetic laboratory with world class instruments for extracting and processing your DNA
A team of molecular biologists, geneticists, bio-informaticians, and computer scientists to decode the DNA and reveal what information it holds accurately
Experience of working on different clinical challenging projects, scientists, doctors, and world renowned institutes
A robust information security system to protect your data
Q. How long does it take for my report to reach me?
A
detailed self-explanatory customized Report provided in 4 to 5 weeks
makes it a convenient experience to get Genetic Test done from
AVISO Healthcare.
Q. How’s a genetic test different from a pathological test?
A genetic test is prognostic and not diagnostic in nature. A diagnostic test will tell you whether the person taking the test has the disease that the doctor suspects on the basis of the symptoms the patient complains of. For instance, a diagnostic test will tell if the patient has high blood glucose level but a genetic test will look for the mutation in the gene responsible for increasing the person’s risk of developing diabetes.
Q. How is it different from annual health check-up and routine lab tests or Dr prescribed tests?
An annual
health check-up or routine lab test includes biochemistry test. Which means
that they look at the presence or absence, quality and/or quantity of a
particular element in your body. For example Thyroid hormones, Vitamin levels,
Calcium level, Sugar etc.
What we
do not realize is that these biochemical elements are existing because of the
DNA. DNA decides how these parameters will work since your birth. Though
environment and lifestyle makes a big impact, DNA plays a vital role.
Several
Sr Exe’s undergo Annual Medical Check-up yet a weak Heart or any hereditary predisposition
/ ailment like Glaucoma, Diabetes etc. do not immediately show up in annual
tests.
Consequences
can be serious and debilitating:
Sources say this happened just
after he completed his Yoga and Fitness exercise for the day
Facts about Heart Diseases in India and World Over:
72% of Indian Corporate employees prone to
heart attack according to ASSOCHAM.
SAP India head,CEO died of Heart Attack.He
was 42 years.
MD of Bajaj Electricals dies at 41 due to
Heart Attack.
McDonalds CEO dies of Heart Attack. He was
60.
CEO Business Connexion, passed away after suffering a heart attack. He was 41.
According to WHO,17.7 million people die each year from cardio vascular Diseases (CVDs), an estimated 31% of all deaths worldwide.
And 80% of all CVD deaths are due to heart attacks and strokes.
Q. At what stage of Life can one take a DNA test?
• Everyone’s body is different, which means everyone’s body reacts
differently to certain foods.
• It is recommended that everyone in the family does it because although
one family, everyone is genetically unique. Any person of any gender and age
can be equally benefitted.
• Which stage in life? Any stage! Your DNA remains same throughout your
life and impact of that DNA on your body is what we reveal through a genetic
test.
• Is this a one-time test? DNA test is done once in a life. However,
various reports can be generated as more research is published.
Q. What
are DNA tests?
DNA
Wellness Screening allows you to screen your DNA for health and wellness traits
including Nutrients, Dietary, Fitness, Health, Skin Care and
Immunity. You can personalize your lifestyle and wellness based on
your unique DNA profile and recommendations. Reports help you and your Advisor
comprising Doctors, Nutritionists, Dieticians, GYM Instructors, Fitness
Trainers to give you correct advice and not give Standard made for all programs
or do trial n’ error.
Q. How is DNA test done at AVISO Healthcare?
The DNA
is extracted from the sample and amplified to look for mutations in the gene
and biological markers to check the person’s risk of developing certain
illness/disease. Right now we have good Indian data for predicting diabetes,
heart, skin, immunity conditions.
In 4 Easy Steps you are done with your DNA Test
from the comfort of your home.
Q. How is AVISO test different from others?
There are
many un-validated tests being offered to consumers, AVISO Healthcare authorized Lab
ONLY uses (most expensive) Illumina machines for 95% to 99% efficacy (used
by 78% of the Global researcher labs). Tests that are invalid or less than are
of no use to the customer and may give False Positive or a False Negative. The
report accuracy, Customer Service and Customer centricity is the hallmark
of AVISO Healthcare.
Q. How do Prices of AVISO DNA Tests Compare with others?
AVISO Healthcare DNA Tests should be compared ONLY with Illumina Machine (Lab) results. We are known for our Reliability | Efficacy | Quality | Timeliness | Superlative Customer Service. We Pride ourselves in being compettive yet not the cheapest as HEALTH is not something we take lightly.
What we desist from Industry Malpractices such as:
Using substandard Chips
Giving inconclusive reports
Rnning half reagents
Reusing chemical reagents
Lab is a state-of-the-art with Illumina instrument. Illumina is the world leader in genetic technology. The testing platform has an acuracy and sensitivity of more than 99%.
Others may use different and lower sensitivity technology or old instruments to process a patient's precious samples.
Consent form is critical as we believe in transparency of our work.
We operate from Authorised ISO certified: ISO 27001:2013 (Data security) and ISO 9001:2015 (quality management system to consistently provide products and services that meet customer and regulatory requirements)
Believe in quantity rather than quality. We report conditions which are well studied and reported and do not get into the race of more markers.
Our report and bioinformatics algorithms takes genetics of Indian ethnicity into account.
Team of geneticists, molecular biologists, computer scientists, and genetic counsellors with more than decades of experience.
There are incidences where Others have manually generated the reports without testing.
Q. Has a Celebrity taken DNA test?
A Case Study: The Angeline Jolie effect
• Predictive genetic testing or pre-symptomatic genetic testing became
extremely popular after Hollywood actor Angelina Jolie underwent
a double mastectomy following a genetic test which showed that she had mutation
in a gene known as BRCA1 that increased her risk of breast and ovarian cancer.
Jolie’s mother had died of cancer and Jolie underwent the procedure to reduce
her chances of developing the condition.
• Jolie’s decision stirred an ethical debate on the need for screening to
look for genetic mutations which are associated with an increased risk of
developing both chronic and life threatening medical conditions.
Top
Indian Cricketer’s including their families have taken DNA tests and more
National and International Level Sports and Fitness Enthusiasts are using the
information from their DNA test to tailor Diet, Nutrition, Exercises aligned to
their body type and reach peak potential.
Q. What is genetic disorder?
Apart
from looking for specific mutation in genes, Gene test also examines structural
changes in the gene - biological markers. Indians with diabetes have some
specific biological markers. So when we test a client who shows the presence of
the same biological marker, we can conclude that he/she is at the risk of
having diabetes at a later stage.
Genetic
disorder is any disease caused by a change in the DNA sequence either in parts
or whole. Some people carry genes of genetic illnesses and might not show any
signs themselves. Symptoms are caused only if two of the problem gene are
inherited. In the case of babies with genetic disorders, a problematic gene is
passed onto the baby by each parent. Some of the common genetic disorders among
children are thalassemia, sickle cell disease, cystic fibrosis, spinal muscular
atrophy, fragileX, hemophilia, and autism. The Genetic Test from
AVISO Healthcare helps become aware of such possible
predispositions.
Q. What else impacts us other than DNA?
When it
comes to your health and traits, DNA is only part of the story. Other variables
come into play, including non-genetic factors, such as your environment and
lifestyle.
Q. What is DNA? What is Gene?
A
gene is the basic physical and functional unit of heredity. Genes are made up
of DNA.
Some
genes act as instructions to make molecules called proteins. However, many
genes do not code for proteins. In humans, genes vary in size from a few
hundred DNA bases to more than 2 million bases. The Human Genome Project
estimated that humans have between 20,000 and 25,000 genes. Every person has
two copies of each gene, one inherited from each parent.
DNA (Deoxyribo Nucleic Acid),
is the hereditary material in humans and almost all other organisms.
Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA). The information in DNA is stored as a code made up of four chemical bases: adenine (A), guanine (G), cytosine (C), and thymine (T).
DNA (Deoxyribo Nucleic Acid), is the hereditary material in humans and almost all other organisms.
Most DNA is located in the cell
nucleus (where it is called nuclear DNA), but a small amount of DNA can also be
found in the mitochondria (where it is called mitochondrial DNA or mtDNA). The
information in DNA is stored as a code made up of four chemical bases: adenine
(A), guanine (G), cytosine (C), and thymine (T).
Did you know via a simple
saliva based DNA test, we can establish our genetic predisposition to
more than 100 medical conditions,
including cancers of different organs, diabetes,
heart attack and stroke. Many people have now become curious
about their medical predispositions because of increased access to personal
genomics. Doctors feel some clients process information well, others panic
without understanding risk of the
potential illness/disease.
Q.
What is genetic testing?
It
is a simple blood test that examines your DNA to check for alterations in your
genes that may lead to illnesses. The test can help doctors identify
defective genes and recommend diagnosis/treatment effectively.
- Early detection and cure - In the case of most
genetic disorders, early diagnosis and intervention play a critical role.
This means early genetic testing will help to prevent, treat, or improve
the quality of life for patients through medication, dietary
modifications, or other therapies. A recent study showcased that it takes
more than seven physicians and four years to diagnose such rare disorders.
- Inherited illness - Do you
know a close relative with inherited genetic disorder? It is vital for
parents in this case to undergo a genetic testing to avoid/eliminate any
doubts. This precautionary step will help doctors understand your family
history in detail and be prepared to fight for the safety of your child.
Q.
What do the results of Genetic Tests mean?
• A positive test result means that the
laboratory found a change in a particular gene, chromosome, or protein of
interest. Depending on the purpose of the test, this result may confirm a
diagnosis, indicate that a person is a carrier of a particular genetic
mutation, identify an increased risk of developing a disease in the future, or
suggest a need for further testing.
• A negative test result means that the
laboratory did not find a change in the gene, chromosome, or protein under
consideration. This result can indicate that a person is not affected by a
particular disorder, is not a carrier of a specific genetic mutation, or does
not have an increased risk of developing a certain disease. However there is
still possibility that any unknown genetic variation can still be a risk
factor.
• A variant of unknown significance
(VUS) can also be found in a genetic sequence for which the association with
disease risk is unclear
Q. Can this DNA
wellness screening tell if someone has a disease?
• No, DNA Wellness Screening is
non-diagnostic test, and the results should not be considered as medical
diagnosis.
• It is unable to detect infectious
agents or biochemical values like cholesterol level, rather it looks at markers
of your general health and wellness that can be improved through your lifestyle
changes.
• For example, it can tell you if you
are genetically predisposed to cardiovascular event or high cholesterol level.
• Any medical concerns or abnormal
results should be discussed with your healthcare service provider.
Q. At what stage of
Life can one take a DNA test?
• Everyone’s body is different, which means
everyone’s body reacts differently to certain foods.
• It is recommended that everyone in
the family does it because although one family, everyone is genetically unique.
Any person of any gender and age can be equally benefitted.
• Which stage in life? Any stage! Your
DNA remains same throughout your life and impact of that DNA on your body is
what we reveal through a genetic test.
• Is this a one-time test? DNA test is done once in a life. However, various reports can be generated as more research is published.
Q. What’s the need for concern at this time to seek preventive healthcare*?
•
India
accounts for approx. 60% of the world’s HEART DISEASE burden. Heart
disease is the No. 1 cause of DEATH also a silent epidemic among Indians. Heart
disease rate among Indians is DOUBLE v/s national averages of western
world.
•
This may be
attributed to an underlying genetic predisposition to metabolic deregulation
and cardiomyopathy, as well as a recent shift of modifiable risk factors
towards increasing consumption of red meats / saturated fats and trans-fats /
junk foods and higher stress in sedentary call-centre workers in India.
•
Heart
disease strikes Indians, 33% earlier vs other demography’s without prior warning.
•
50%
heart attacks in Indian men occur < 50 years of age & 25% < 40 years
of age.
•
Indian women have
high mortality rates from cardiac disease as well.
•
India is home to
second-largest number of adults with diabetes worldwide DIABETES can lead to
heart diseases, kidney diseases, neuropathy, eye problems and liver ailments.
It affects practically every organ. In
India, the number of people with diabetes is expected to rise from 77 million
in 2019 to 101 million in 2030 to 134 million in 2045.
Q. As Indians how prone are we prone to Heart
Disease or Diabetes?
Deaths due to heart attacks up 53% in 5 yrs
*Indian Men get HEART ATTACKS in 50% cases before 50 yrs, 25% cases before 40
yrs Heart disease strikes
Indians, 33% earlier vs other demography’s without prior warning.
There is strong evidence that Type 2 Diabetes has a strong genetic
basis.
Influencing factors include Ethnicity, Family History, History of
Gestational Diabetes mellitus. The lifetime risk of developing the
disease is ~40% in offspring of one parent with type 2 diabetes, greater if the mother
is affected and ~70% if both parents have diabetes.
Advances in genotyping technology
during the last 5 years have facilitated rapid progress in large-scale accurate
and reliable genetic predisposition via DNA Testing for preventive care and
early cure. *Source:http://indianheartassociation.org/why-indians-why-south-asians/&
**Advances in genotyping technology during the last 5
years have facilitated rapid progress in large-scale accurate and reliable genetic predisposition via DNA Testing for
preventive care and early cure. Advances in genotyping technology during the last 5 years have facilitated
rapid progress in large-scale accurate
and reliable genetic predisposition via DNA Testing for preventive care and
early cure. Advances in genotyping
technology during the last 5 years have facilitated rapid progress in
large-scale accurate and reliable
genetic predisposition via DNA Testing for preventive care and early cure
**Source:https://www.cnbctv18.com/views/diabetes-a-major-health-challenge-for-india-8330931.htm
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